Description:Na+/K+ATPaseinhibitor
ChemicalName:4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Inhibitsmembrane-boundα-subunitsoftheNa+/K+ATPasepumpinmyocytes.IncreasesRGS2proteinlevelsinprimaryvascularsmoothmusclecellsthroughanNa+/K+ATPasepump-dependentmechanism.
TechnicalData
| M.Wt | 780.94 |
| Formula | C41H64O14 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 20830-75-5 |
| PubChemID | 12940973 |
| InChIKey | LTMHDMANZUZIPE-SYUUTQQWSA-N |
| Smiles | O=C1OC[C@]([C@H]5CC[C@]4(O)[C@]3([H])CC[C@]2([H])C[C@@H](O[C@]6([H])O[C@H](C)[C@@H](O[C@@]7([H])C[C@H](O)[C@H](O[C@]8([H])O[C@H](C)[C@@H](O)[C@@H](O)C8)[C@@H](C)O7)[C@@H](O)C6)CC[C@@](C)2[C@]([H])3C[C@@H](O)[C@]45C)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 78.09 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight780.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.28mL | 6.4mL | 12.81mL |
| 5mM | 0.26mL | 1.28mL | 2.56mL |
| 10mM | 0.13mL | 0.64mL | 1.28mL |
| 50mM | 0.03mL | 0.13mL | 0.26mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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