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Tocris/NCX 4040/4531/50/50 mg

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货号: 4531/50

品牌: Tocris

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Description: NO-donating aspirin; anti-inflammatory and antitumor

Chemical Name: 2-(Acetyloxy)benzoic acid 4-[(nitrooxy)methyl]phenyl ester

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

NO-donating aspirin; anti-inflammatory. Blocks inflammatory mediator production in isolated human monocytes (IC₅₀ values are 0.07, 0.13, 0.15 and 0.18 μM for IL-1β, PGE₂, IL-10 and TNF-α respectively). Decreases COX-2 expression (IC₅₀ = 0.13 μM); disrupts proteasome-mediated degradation of iκB-α. Antiproliferative in HCT116 colon cancer cells; sensitizes drug-resistant ovarian tumor cells to cisplatin (Cat. No. 2251).

Technical Data

M. Wt	331.28
Formula	C₁₆H₁₃NO₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	287118-97-2
PubChem ID	9818919
InChI Key	CTHNKWFUDCMLIQ-UHFFFAOYSA-N
Smiles	O=C(C)OC1=C(C(OC2=CC=C(CO[N+]([O-])=O)C=C2)=O)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.13	100
	ethanol	1.66	5

Preparing Stock Solutions

The following data is based on the product molecular weight 331.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.19 mL
5 mM	0.6 mL	3.02 mL	6.04 mL
10 mM	0.3 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Ricciotti et al (2010) NCX 4040, a nitric oxide-donating aspirin, exerts anti-inflammatory effects through inhibition of I kappa B-alpha degradation in human monocytes. J.Immunol. 184 2140 PMID: 20065114

Yamakawa et al (2008) Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism. Biol.Pharm.Bull. 31 916 PMID: 18451518

Bratasz et al (2008) NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols. J.Transl.Med. 6 9 PMID: 18302761

Gao et al (2008) Immunomodulatory activity of synthetic triterpenoids: inhibition of lymphocyte proliferation, cell-mediated cytotoxicity, and cytokine gene expression through suppression of NF-κB. Immunopharmacol.Immunotoxicol. 30 581 PMID: 18608528

Keywords: NCX 4040, supplier, NCX4040, NO, nitric, oxide, donating, donors, aspirin, para, cyclooxygenase, inhibitors, inhibits, anti-inflammatory, inflammation, NSAIDs, antitumor, cisplatin, resistant, Cyclooxygenase, NO, Donors, /, Precursors, Cyclooxygenase, Tocris Bioscience

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