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Tocris/TC-I 15/4527/10/10 mg

价格: ¥2700.00 市场价: 4500.00

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货号: 4527/10

品牌: Tocris

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Description: Potent α₂β₁ inhibitor; displays antithrombotic activity in vivo

Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent α₂β₁ integrin inhibitor (IC₅₀ values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for α₂β₁ over α_vβ₃, α₅β₁, α₆β₁ and α_IIbβ₃ at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo; prevents ferric chloride-induced clot formation in mice.

Licensing Information

Sold under license from the University of Pennsylvania.

Compound Libraries

TC-I 15 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	520.62
Formula	C₂₃H₂₈N₄O₆S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	916734-43-5
PubChem ID	90488948
InChI Key	XKLHCUGVLCGKKX-RBUKOAKNSA-N
Smiles	CC1(C)SCN(S(C3=CC=CC=C3)(=O)=O)[C@@H]1[C@@](N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1.1eq. NaOH	13.02	25
	DMSO	52.06	100
	ethanol	52.06	100

Preparing Stock Solutions

The following data is based on the product molecular weight 520.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.92 mL	9.6 mL	19.21 mL
5 mM	0.38 mL	1.92 mL	3.84 mL
10 mM	0.19 mL	0.96 mL	1.92 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Borza et al (2012) Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 23 1027 PMID: 22440900

Miller et al (2009) Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 106 719 PMID: 19141632

Keywords: TC-I 15, supplier, TC-I15, integrins, receptors, a2b1, alpha2beta1, α2β1, inhibitors, inhibits, potent, selective, active, in, vivo, antithrombotics, collagen, Integrins, Cell, Adhesion, Molecules, Integrins, Tocris Bioscience

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