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ClC-Kachloridechannelblocker(IC50=100μM).Blocksthemaxichloridechannelinapicalmembranesfromhumanplacenta.DisplaysantagoNISTicactivityatTRPM4andTRPC4channels;potentiatesagonist-inducedTRPV1currents(IC50=4.88μMinratDRGneurons).InhibitsRAD51recombinaseactivity(KD=2μM).
| M.Wt | 498.48 |
| Formula | C16H8N2Na2O6S4 |
| Storage | Storeat+4°C |
| Purity | ≥95%(HPLC) |
| CASNumber | 67483-13-0 |
| PubChemID | 5702690 |
| InChIKey | GEPAYBXVXXBSKP-SEPHDYHBSA-L |
| Smiles | [Na+].[Na+].[O-]S(=O)(=O)C1=C(C=CC2=C(C=C(C=C2)N=C=S)S([O-])(=O)=O)C=CC(=C1)N=C=S |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| Potassiumbicarbonate(0.1M) | 4.98 | 10 | |
| DMSO | 4.98 | 10 |
Thefollowingdataisbasedontheproductmolecularweight498.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.01mL | 10.03mL | 20.06mL |
| 5mM | 0.4mL | 2.01mL | 4.01mL |
| 10mM | 0.2mL | 1mL | 2.01mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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