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Potentlyinducesdifferentiationofhumanmesenchymalstemcellsintochondrocytes(EC50=100nM).Reducesdiseaseseverityinamousemodelofosteoarthritis;displaysprotectiveeffectsagainstosteoarthriticstimuliinmaturechondrocytesinvitro.
KartogeninisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight317.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Johnsonetal(2012)Astemcell-basedapproachtocartilagerepair.Science336717PMID:22491093
Keywords:Kartogenin,supplier,Supplier,mesenchymal,stem,cell,differentiation,differentiators,potently,inducers,chondrocytes,cartilage,osteoarthritis,Mesenchymal,Stem,Cells,Mesenchymal,Stem,Cells,TocrisBioscience
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