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Tocris/Paliperidone/4493/50/50 mg

价格: ¥6420.00 市场价: 10700.00

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货号: 4493/50

品牌: Tocris

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Description: Atypical antipsychotic; 5-HT_2A and D₂ antagonist

Alternative Names: 9-Hydroxyrisperidone, 9-OH-risperidone

Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Atypical antipsychotic; metabolite of risperidone (Cat. No. 2865). Exhibits high affinity for 5-HT_2A receptors (K_i = 0.4 nM for cloned human 5-HT_2A receptors). Also displays nanomolar affinity for human D₂ receptors.

Technical Data

M. Wt	426.48
Formula	C₂₃H₂₇FN₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	144598-75-4
PubChem ID	115237
InChI Key	PMXMIIMHBWHSKN-UHFFFAOYSA-N
Smiles	FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(C(O)CCC5)N5C4=O)CC3)=NO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.26	10

Preparing Stock Solutions

The following data is based on the product molecular weight 426.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.72 mL	23.45 mL
5 mM	0.47 mL	2.34 mL	4.69 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Schotte et al (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 124 57 PMID: 8935801

Dremencov et al (2007) Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons. Psychopharmacology 194 63 PMID: 17530476

Megens and Awouters et al (1994) In vivo pharmacological profile of 9-hydroxyrisperidone, the major metabolite of the novel antipsychotic risperidone. 33 399 PMID:

Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 55 5 PMID: 7520908

Keywords: Paliperidone, supplier, atypical, antipsychotic, 5-ht2a, serotonergic, serotonin, antagonists, dopamine, dopaminergic, d2, high, affinity, 9-OH-risperidone, 9-hydroxyrisperidone, 9-Hydroxyrisperidone, 9-OH-risperidone, 5-HT2A, Receptors, D2, Receptors, 5-HT2A, Receptors, Tocris Bioscience

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