Chemical Name:N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine
Purity: ≥99% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). Selective for P2X7 receptors (IC50 > 5-10 μM for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).
Compound Libraries
A 804598 is also offered as part of the
Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
M. Wt
315.37
Formula
C19H17N5
Storage
Store at -20°C
Purity
≥99% (HPLC)
CAS Number
1125758-85-1
PubChem ID
53325874
InChI Key
PQYCRDPLPKGSME-AWEZNQCLSA-N
Smiles
C[C@@H](C3=CC=CC=C3)NC(NC2=CC=CC1=NC=CC=C12)=NC#N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
31.54
100
Preparing Stock Solutions
The following data is based on the product molecular weight 315.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.17 mL
15.85 mL
31.71 mL
5 mM
0.63 mL
3.17 mL
6.34 mL
10 mM
0.32 mL
1.59 mL
3.17 mL
50 mM
0.06 mL
0.32 mL
0.63 mL
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
Select another language:
View SDS
References
References are publications that support the products' biological activity.
Donnelly-Robertset al (2009) [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology 56 223 PMID: 18602931
Ableet al (2011) Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat. Br.J.Pharmacol. 162 405 PMID: 20840537
购物车为空，快去购物吧！
4000-520-616
咨询顾问
特别 提示
