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Tocris/Rivastigmine tartrate/4440/50/50 mg

价格: ¥1668.00 市场价: 2780.00

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货号: 4440/50

品牌: Tocris

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Description: Dual AChE and BChE inhibitor

Alternative Names: ENA 713

Chemical Name: N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester (2R,3R)-2,3-dihydroxybutanedioate

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Dual cholinesterase inhibitor (ChEI); inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Brain penetrant.

Compound Libraries

Rivastigmine tartrate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	400.42
Formula	C₁₄H₂₂N₂O₂.C₄H₆O₆
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	129101-54-8
PubChem ID	6918078
InChI Key	GWHQHAUAXRMMOT-MBANBULQSA-N
Smiles	O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.04	100
	ethanol	40.04	100
	water	40.04	100

Preparing Stock Solutions

The following data is based on the product molecular weight 400.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.5 mL	12.49 mL	24.97 mL
5 mM	0.5 mL	2.5 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.5 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Groner et al (2007) The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 71 1610 PMID: 17347320

Luo et al (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 49 2174 PMID: 16570913

Mehta et al (2012) New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis PMID: 22216416

Bailey et al (2011) Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 6 e21954 PMID: 21799757

Keywords: Rivastigmine tartrate, supplier, acetylcholinesterase, AChE, butyrylcholinesterase, BChE, inhibitors, inhibits, ChEI, brain, penetrant, ENA713, Rivastigmine, tartrate, ENA, 713, Cholinesterases, Cholinesterases, Tocris Bioscience

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