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Tocris/YC 1/4307/50/50 mg

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货号: 4307/50

品牌: Tocris

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Description: Soluble guanylyl cyclase (sGC) activator; induces G₁ cell cycle arrest

Chemical Name: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC₅₀ = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC₅₀ = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G₁ cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

Compound Libraries

YC 1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	304.34
Formula	C₁₉H₁₆N₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	170632-47-0
PubChem ID	5712
InChI Key	OQQVFCKUDYMWGV-UHFFFAOYSA-N
Smiles	OCC4=CC=C(O4)C2=NN(CC3=CC=CC=C3)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.43	100
	ethanol	15.22	50

Preparing Stock Solutions

The following data is based on the product molecular weight 304.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.29 mL	16.43 mL	32.86 mL
5 mM	0.66 mL	3.29 mL	6.57 mL
10 mM	0.33 mL	1.64 mL	3.29 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Ko et al (1994) YC-1, a novel activator of platelet guanylate cyclase. Blood. 84 4226 PMID: 7527671

Martin et al (2001) YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components. Proc.Natl.Sci.U.S.A. 98 12938 PMID: 11687640

Wang et al (2005) YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. J.Pharmacol.Exp.Ther. 312 917 PMID: 15525795

Teixeira et al (2006) Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4 J.Pharmacol.Exp.Ther. 317 258 PMID: 16352702

Keywords: YC 1, supplier, YC1, soluble, guanylyl, cyclase, sGC, activators, platelet, aggregation, cGMP, antiproliferatives, G1, cell, cycle, arrest, inducers, p21, CDK2, Guanylyl, Cyclase, Cell, Cycle, Inhibitors, Enzyme, Substrates, /, Activators, Guanylyl, Cyclase, Tocris Bioscience

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