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Tocris/ICA 069673/4305/50/50 mg

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货号: 4305/50

品牌: Tocris

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Description: K_V7.2/K_V7.3 channel opener

Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective K_V7.2/K_V7.3 (KCNQ2/3) channel opener (EC₅₀ = 0.69 μM). Exhibits 20-fold selectivity for K_V7.2/K_V7.3 over K_V7.3/K_V7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Compound Libraries

ICA 069673 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	269.63
Formula	C₁₁H₆ClF₂N₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	582323-16-8
PubChem ID	10149311
InChI Key	IIBSHMFXVWTQSJ-UHFFFAOYSA-N
Smiles	ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.96	100
	ethanol	6.74	25

Preparing Stock Solutions

The following data is based on the product molecular weight 269.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.54 mL	37.09 mL
5 mM	0.74 mL	3.71 mL	7.42 mL
10 mM	0.37 mL	1.85 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Amato et al (2011) N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med.Chem.Lett. 2 481 PMID: 24900334

Provence et al (2015) The novel K_v7.2/K_v7.3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility. J.Pharmacol.Exp.Ther. 354 290 PMID: 26087697

Keywords: ICA 069673, supplier, ICA069673, KCNQ2, KCNQ3, kv7.2, kv7.3, channel, opener, potassium, K+, voltage, gated, potassium, channel, openers, Kv, Voltage-Gated, Potassium, Channels, Voltage-Gated, Potassium, Channels, Tocris Bioscience

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