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Tocris/SBE 13 hydrochloride/4292/50/50 mg

价格: ¥5028.00 市场价: 8380.00

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货号: 4292/50

品牌: Tocris

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Description: Potent and selective PLK1 inhibitor

Chemical Name: N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective inhibitor of PLK1 (IC₅₀ values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G₀/G₁ in primary cells.

Compound Libraries

SBE 13 hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	479.4
Formula	C₂₄H₂₇ClN₂O₄.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1052532-15-6
PubChem ID	11948807
InChI Key	QBGSVDJLQQXEGG-UHFFFAOYSA-N
Smiles	ClC(N=C3)=CC=C3COC1=C(OC)C=C(CNCCC2=CC(OC)=C(OC)C=C2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.94	100
	ethanol	4.79	10mM with gentle warming
	water	4.79	10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 479.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.43 mL	20.86 mL
5 mM	0.42 mL	2.09 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Eckerdt (2010) Freezing Polo in its sleep: targeting the inactive conformation of Polo-like kinase 1 in cancer cells. Cell Cycle 9 862 PMID: 20348843

Keppner et al (2010) Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle 9 761 PMID: 20139717

Liu (2010) SBE13 joins the family of Polo-like kinase 1 (Plk1) inhibitors. Cell Cycle 9 445 PMID: 20130451

Keppner et al (2011) Fate of primary cells at the G₁/S boundary after Polo-like kinase 1 inhibition by SBE13. Cell Cycle 10 708 PMID: 21301227

Keppner et al (2009) Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem 4 1806 PMID: 19746360

Keywords: SBE 13 hydrochloride, supplier, SBE13, polo-like, kinases, plk1, plk, selective, potent, Polo-like, Kinase, Mitosis, Polo-like, Kinase, Tocris Bioscience

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