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Tocris/ISO 1/4288/50/50 mg

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货号: 4288/50

品牌: Tocris

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Description: Macrophage migration inhibitory factor (MIF) inhibitor

Chemical Name: 4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Macrophage migration inhibitory factor (MIF) inhibitor (IC₅₀ = 7 μM); inhibits MIF tautomerase activity in vitro and in vivo. Protective against mouse models of streptozotocin-induced diabetes mellitus; blocks anti-inflammatory response following LPS exposure and increases survival. Inhibits airway remodeling in a mouse model of chronic asthma. Cell permeable; orally bioavailable.

Compound Libraries

ISO 1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	235.24
Formula	C₁₂H₁₃NO₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	478336-92-4
PubChem ID	6098948
InChI Key	CLVQGFPQFNASJH-UHFFFAOYSA-N
Smiles	OC(C=C2)=CC=C2C1=NOC(CC(OC)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.52	100
	ethanol	23.52	100

Preparing Stock Solutions

The following data is based on the product molecular weight 235.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.25 mL	21.25 mL	42.51 mL
5 mM	0.85 mL	4.25 mL	8.5 mL
10 mM	0.43 mL	2.13 mL	4.25 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Al-Abed et al (2005) ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J.Biol.Chem. 280 36541 PMID: 16115897

Cvetkovic et al (2005) Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology 146 2942 PMID: 15790730

Chen et al (2010) ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma. Mol.Med. 16 400 PMID: 20485865

Lubetsky et al (2002) The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J.Biol.Chem. 277 24976 PMID: 11997397

Keywords: ISO 1, supplier, ISO1, macrophage, migration, inhibitory, factor, antagonists, inhibits, inhibitors, tautomerase, MIF, Cytokines, Cytokines, Tocris Bioscience

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