Chemical Name: Polyinosinic-polycytidylic acid sodium salt
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 (Cat.No. 6142). Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant.
Technical Data
Formula
(C10H13N4O8P)x.(C9H14N3O8P)x
Storage
Store at -20°C
CAS Number
24939-03-5
PubChem ID
32744
InChI Key
ACEVNMQDUCOKHT-ZLOOHWKQSA-N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
water
3
0
Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Robbinset al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616 PMID: 12960048
Rouaset al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767 PMID: 15096480
Westet al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476 PMID: 21525932
Sprangeret al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554
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