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Tocris/TAK 715/4254/10/10 mg

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货号: 4254/10

品牌: Tocris

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Description: Potent p38 MAPK inhibitor; anti-inflammatory

Chemical Name: N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Inhibitor of p38 MAPK (IC₅₀ = 7.1 nM for p38 MAPKα). Also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 kinases by more than 80%, including CK1δ/ε. Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable.

Compound Libraries

TAK 715 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	399.51
Formula	C₂₄H₂₁N₃OS
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	303162-79-0
PubChem ID	90488922
InChI Key	BRYAJHADJWBFQY-UHFFFAOYSA-N
Smiles	CCC1=NC(C3=CC(C)=CC=C3)=C(C2=C(NC(C4=CC=CC=C4)=O)N=CC=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.95	100
	ethanol	19.98	50

Preparing Stock Solutions

The following data is based on the product molecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.5 mL	12.52 mL	25.03 mL
5 mM	0.5 mL	2.5 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.5 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Miwatashi et al (2005) Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-{2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J.Med.Chem. 48 5966 PMID: 16162000

Verkaar et al (2011) Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Chem.Biol. 18 485 PMID: 21513885

Keywords: TAK 715, supplier, TAK715, p38, MAPK, inhibitors, Mitogen-activated, protein, kinase, anti-inflammatory, inhibits, wnt, b-catenin, inhibitor, beta-catenin, casein, kinase, p38, Casein, Kinase, 1, Beta-catenin, p38, Tocris Bioscience

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