Description:Calcineurinphosphataseinhibitor;analogofFK506(Cat.No.3631)
AlternativeNames:FK520,FR900520
ChemicalName:(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
AnalogofFK506(Cat.No.3631);bindstoFK506-bindingprotein12(FKBP12)inordertoinhibitcalcineurinphosphataseactivity(IC50=49nM)andactivationofnuclearfactorofactivatedTcells(NFAT).Displaysantifungalandimmunosuppressiveactivities.
TechnicalData
| M.Wt | 792.01 |
| Formula | C43H69NO12 |
| Storage | Storeat-20°C |
| CASNumber | 104987-12-4 |
| PubChemID | 5282071 |
| InChIKey | ZDQSOHOQTUFQEM-NURRSENYSA-N |
| Smiles | O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 39.6 | 50 |
| ethanol | 39.6 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight792.01.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.26mL | 6.31mL | 12.63mL |
| 5mM | 0.25mL | 1.26mL | 2.53mL |
| 10mM | 0.13mL | 0.63mL | 1.26mL |
| 50mM | 0.03mL | 0.13mL | 0.25mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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