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Tocris/WY 45233 succinate/4194/10/10 mg

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货号: 4194/10

品牌: Tocris

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Description: Dual serotonin/noradrenalin re-uptake inhibitor

Alternative Names: Desvenlafaxine

Chemical Name: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (K_i values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [³H]5-HT and [³H]NE uptake (IC₅₀ values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

WY 45233 succinate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	381.46
Formula	C₁₆H₂₅NO₂.C₄H₆O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	448904-47-0
PubChem ID	9800068
InChI Key	ORUUBRMVQCKYHB-UHFFFAOYSA-N
Smiles	OC1(C(CN(C)C)C2=CC=C(O)C=C2)CCCCC1.O=C(CCC(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.15	100
	water	19.07	50

Preparing Stock Solutions

The following data is based on the product molecular weight 381.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.11 mL	26.22 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Alfinito et al (2006) Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats. Brain Res. 1098 71 PMID: 16764833

Deecher et al (2006) Desvenlafaxine succinate: a new serotonin and norepinephrine reuptake inhibitor. J.Pharmacol.Exp.Ther. 318 657 PMID: 16675639

Mason et al (2007) Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter. J.Pharmacol.Exp.Ther. 323 720 PMID: 17673606

Keywords: WY 45233 succinate, supplier, WY45233, pfizer, serotonin, 5-HT, norepinephrine, noradrenalin, noradrenaline, adrenergic, sert, net, transporters, reuptake, inhibitors, inhibits, snri, Desvenlafaxine, 5-HT, Transporters, Adrenergic, Transporters, 5-HT, Transporters, Tocris Bioscience

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