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Tocris/NS 5806/4166/50/50 mg

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货号: 4166/50

品牌: Tocris

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Description: K_V4.3 channel activator

Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

K_V4.3 channel activator; mediates the transient outward K⁺ current (I_to). Increases I_Kv4.3 peak current amplitude in CHO-K1 cells expressing K_V4.3 and KChIP2 (EC₅₀ = 5.3 μM). Inhibits K_V1.4-mediated currents independently of KChIP2. Also slows the decay of K_V4.2 and K_V4.3 currents in the presence of KChIP2.

Compound Libraries

NS 5806 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	574.07
Formula	C₁₆H₈Br₂F₆N₆O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	426834-69-7
PubChem ID	11642685
InChI Key	UZWJWROOLOOCPQ-UHFFFAOYSA-N
Smiles	BrC1=CC(Br)=CC(C2=NN=NN2)=C1NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	57.41	100
	ethanol	28.7	50

Preparing Stock Solutions

The following data is based on the product molecular weight 574.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.74 mL	8.71 mL	17.42 mL
5 mM	0.35 mL	1.74 mL	3.48 mL
10 mM	0.17 mL	0.87 mL	1.74 mL
50 mM	0.03 mL	0.17 mL	0.35 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Calloe et al (2009) A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc.Res. 81 686 PMID: 19073629

Calloe et al (2010) Differential effects of the transient outward K⁺ current activator NS5806 in the canine left ventricle. J.Mol.Cell.Cardiol. 48 191 PMID: 19632239

Lundby et al (2010) Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2. Br.J.Pharmacol. 160 2028 PMID: 20649599

Keywords: NS 5806, supplier, NS5806, kv4.3, channels, ito, transient, outward, potassium, currents, activators, voltage-gated, voltage-dependent, K+, Voltage-Gated, Potassium, Channels, Voltage-Gated, Potassium, Channels, Tocris Bioscience

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