BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Selectivereversetranscriptaseinhibitor.Exhibits100-foldselectivityforHIVreversetranscriptaseoverDNApolymeraseα.SuppressesHIV-1replicationandenhancescellviABIlityinHIV-1infectedTcells.Attenuatesgrowthofmultiplemyeloma(MM)cellsinvitroandreducesgrowthofMMtumorxenograftsinmice.Orallybioavailableandbrainpenetrant.Antiretroviralagent.AlsodecreasesCRISPR-mediatedhomologydirectedrepair(HDR)efficiency.
LicensingInformation
SoldforresearchpurposesunderagreementfromViiv.
TechnicalData
| M.Wt | 267.24 |
| Formula | C10H13N5O4 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 30516-87-1 |
| PubChemID | 35370 |
| InChIKey | HBOMLICNUCNMMY-XLPZGREQSA-N |
| Smiles | O=C1N([C@@H]2O[C@H](CO)[C@@H](N=[N+]=[N-])C2)C=C(C)C(N1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 26.72 | 100 |
| water | 13.36 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight267.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 3.74mL | 18.71mL | 37.42mL |
| 5mM | 0.75mL | 3.74mL | 7.48mL |
| 10mM | 0.37mL | 1.87mL | 3.74mL |
| 50mM | 0.07mL | 0.37mL | 0.75mL |
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