Chemical Name:N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide
Purity: ≥99% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.
Technical Data
M. Wt
307.39
Formula
C19H21N3O
Storage
Store at RT
Purity
≥99% (HPLC)
CAS Number
226878-01-9
PubChem ID
7067728
InChI Key
ZKFVOZCCAXQXBU-UHFFFAOYSA-N
Smiles
O=C(C4=NC(C=CC=C5)=C5N=C4)NC1(CC3C2)CC(C3)CC2C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
15.37
50
ethanol
15.37
50
Preparing Stock Solutions
The following data is based on the product molecular weight 307.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.25 mL
16.27 mL
32.53 mL
5 mM
0.65 mL
3.25 mL
6.51 mL
10 mM
0.33 mL
1.63 mL
3.25 mL
50 mM
0.07 mL
0.33 mL
0.65 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Lavreysenet al (2003) [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol.Pharmacol. 63 1082 PMID: 12695537
Mabireet al (2005) Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. J.Med.Chem. 48 2134 PMID: 15771457
van Wagenenet al (2000) Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist. Abstr.Soc.Neurosci. Program No. 618.3. PMID:
Keywords: NPS 2390, supplier, NPS2390, type, I, metabotropic, glutamate, mglu, mglur1, mglur5, antagonists, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
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