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Tocris/Pioglitazone hydrochloride/4124/50/50 mg

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货号: 4124/50

品牌: Tocris

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Description: Selective PPARγ agonist; antidiabetic agent

Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective PPARγ agonist (EC₅₀ = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity.

Compound Libraries

Pioglitazone hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	392.9
Formula	C₁₉H₂₀N₂O₃S.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	112529-15-4
PubChem ID	60560
InChI Key	GHUUBYQTCDQWRA-UHFFFAOYSA-N
Smiles	O=C(S3)NC(C3CC(C=C2)=CC=C2OCCC1=NC=C(CC)C=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.82	25

Preparing Stock Solutions

The following data is based on the product molecular weight 392.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.73 mL	25.45 mL
5 mM	0.51 mL	2.55 mL	5.09 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907

Sakamoto et al (2000) Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem.Biophys.Res.Commun. 278 704 PMID: 11095972

Smith (2001) Pioglitazone: mechanism of action. Int.J.Clin.Pract.Suppl. 121 13 PMID: 11594239

Momose et al (2002) Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. J.Med.Chem. 45 1518 PMID: 11906293

Keywords: Pioglitazone hydrochloride, supplier, PPARg, PPARgamma, PPARγ, peroxisome, proliferator, activated, receptors, nuclear, agonists, antidiabetic, agents, PPARgamma, Receptors, PPARgamma, Receptors, Tocris Bioscience

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