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ClassIAantiarrythmic;reducesbothNa+andK+channelcurrents,includingINa,IKrandIKs.ProlongsQTandinducestorsadedepointes(TdP).
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight324.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Caballeroetal(2003)EffectsofflecainideandquinidineonKv4.2currents:voltagedependenceandroleofS6valines.Br.J.Pharmacol.1381475PMID:12721103
Borggrefeetal(2005)ShortQTsyndromegenotype-genotypecorrelations.J.Electrocardiol.3875PMID:16226079
Wuetal(2008)Roleoflatesodiumcurrentinmodulatingtheproarrhythmicandantiarrhythmiceffectsofquinidine.HeartRhythm.51726PMID:19084812
Keywords:Quinidine,supplier,sodium,Na+,potassium,K+,channel,blockers,IKr,IKs,IK1,IK-ATP,Ito,INa,antiarrhythmic,class,1A,torsade,de,pointes,prolongs,qt,interval,Other,Channel,Modulators,Other,Channel,Modulators,TocrisBioscience
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