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Tocris/MC 1568/4077/50/50 mg

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货号: 4077/50

品牌: Tocris

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Description: Selective HDAC class II (IIa) inhibitor

Chemical Name: 3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

Purity: ≥96% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective inhibitor of class IIa histone deacetylases (HDACs). Exhibits tissue-selective inhibition between members of class II deacetylases in vivo; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. Arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Displays no inhibition of class I HDAC activity or expression.

Compound Libraries

MC 1568 is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	314.31
Formula	C₁₇H₁₅FN₂O₃
Storage	Store at +4°C
Purity	≥96% (HPLC)
CAS Number	852475-26-4
PubChem ID	11381449
InChI Key	QRDAPCMJAOQZSU-KQQUZDAGSA-N
Smiles	CN1C=C(/C=C/C(C2=CC(F)=CC=C2)=O)C=C1/C=C/C(NO)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.43	100

Preparing Stock Solutions

The following data is based on the product molecular weight 314.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.18 mL	15.91 mL	31.82 mL
5 mM	0.64 mL	3.18 mL	6.36 mL
10 mM	0.32 mL	1.59 mL	3.18 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Mai et al (2005) Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamines. J.Med.Chem. 48 3344 PMID: 15857140

Mai et al (2007) Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia. Mol.Pharmacol. 72 1111 PMID: 17666592

Nebbioso et al (2009) Selective class II HDAC inhibitors may impaor myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO J. 10 776 PMID:

Keywords: MC 1568, supplier, MC1568, HDAC, selective, inhibitors, inhibits, histone, deacetylase, class, II, IIa, HDAC4, epigenetics, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience

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