Description:Microtubulest
ABIlizer
ChemicalName:[2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylesterbenzenepropanoicacid
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Bindsandstabilizesmicrotubules;leadstocellcyclearrestandapoptosis.Displayssignificantantitumoractivityinovarianandgastrictumors.PreventsmicrotubuledepolymerizationanddisassemblyintheabsenceofGTP.Exhibitscytotoxicactivity.
TechnicalData
| M.Wt | 807.88 |
| Formula | C43H53NO14 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 114977-28-5 |
| PubChemID | 148124 |
| InChIKey | ZDZOTLJHXYCWBA-VCVYQWHSSA-N |
| Smiles | O[C@@H]1C4=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C[C@@](C(C)4C)(O)[C@@H](OC(C6=CC=CC=C6)=O)[C@@]([C@@]3(OC(C)=O)[C@H](OC3)C[C@@H]2O)([H])[C@]2(C)C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 80.79 | 100 |
| ethanol | 80.79 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight807.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.24mL | 6.19mL | 12.38mL |
| 5mM | 0.25mL | 1.24mL | 2.48mL |
| 10mM | 0.12mL | 0.62mL | 1.24mL |
| 50mM | 0.02mL | 0.12mL | 0.25mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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