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AdenosineA2Areceptor(AA2AR)antagonist(Kivaluesare643and46nMforratandhumanAA2ARsrespectively).MostactiveAA2ARantagonistforhumanreceptors.DisplaysactivityinthetreatmentofParkinson'sdiseaseinvivo;improvesparkinsonianmotordeficitsandtremors.Exhibitsneuroprotectiveandanti-inflammatoryeffects.
ANR94isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight207.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Pinnaetal(2010)AnewethyladenineantagonistofadenosineA2Areceptors:Behavioralandbiochemicalcharacterizationasanantiparkinsoniandrug.Neuropharmacology58613PMID:19951715
Volpinietal(2010)AdenosineA2Areceptorantagonists:New8-substituted9-ethyladeninesastoolsforinvivoratmodelsofParkinson'sdisease.Chem.Med.Chem.41010PMID:
Keywords:ANR94,supplier,ANR94,adenosine,A2A,receptor,antagonist,AA2AR,antagonists,antiparkinsonian,activity,Adenosine,A2A,Receptors,Adenosine,A2A,Receptors,TocrisBioscience
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