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Tocris/SC 236/3919/10/10 mg

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货号: 3919/10

品牌: Tocris

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Description: Selective cyclooxygenase-2 (COX-2) inhibitor

Alternative Names: SC 58236

Chemical Name: 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective COX-2 inhibitor (IC₅₀ values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

SC 236 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	401.79
Formula	C₁₆H₁₁ClF₃N₃O₂S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	170569-86-5
PubChem ID	9865808
InChI Key	NSQNZEUFHPTJME-UHFFFAOYSA-N
Smiles	ClC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.18	100
	ethanol	40.18	100

Preparing Stock Solutions

The following data is based on the product molecular weight 401.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.44 mL	24.89 mL
5 mM	0.5 mL	2.49 mL	4.98 mL
10 mM	0.25 mL	1.24 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Gierse et al (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 271 15810 PMID: 8663121

Roche-Nagle et al (2004) Antimetastatic activity of a cyclooxygenase-2 inhibitor. Br.J.Cancer 91 359 PMID: 15213717

Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J.Med.Chem. 40 1347 PMID: 9135032

Keywords: SC 236, supplier, SC236, SC58236, selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Pfizer, SC, 58236, Cyclooxygenase, Cyclooxygenase, Tocris Bioscience

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