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Tocris/Licarbazepine/3865/50/50 mg

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货号: 3865/50

品牌: Tocris

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Description: Active metabolite of oxcarbazepine (Cat. No. 3864)

Alternative Names: GP 47779

Chemical Name: 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Active metabolite of oxcarbazepine (Cat. No. 3864). Produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Displays anticonvulsant activity; exhibits minor potentiation of GABA_A receptor currents.

Compound Libraries

Licarbazepine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	254.28
Formula	C₁₅H₁₄N₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	29331-92-8
PubChem ID	114709
InChI Key	BMPDWHIDQYTSHX-UHFFFAOYSA-N
Smiles	NC(N2C1=CC=CC=C1C(O)CC3=C2C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.43	100
	ethanol	12.71	50

Preparing Stock Solutions

The following data is based on the product molecular weight 254.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.93 mL	19.66 mL	39.33 mL
5 mM	0.79 mL	3.93 mL	7.87 mL
10 mM	0.39 mL	1.97 mL	3.93 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Calabresi et al (1995) Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission. Epilepsia 36 990 PMID: 7555963

Benes et al (1999) Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J.Med.Chem. 42 2582 PMID: 10411478

Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABA_A activation and aggravates absence seizures. Epilepsia 50 83 PMID: 18717705

Keywords: Licarbazepine, supplier, antiepileptics, anticonvulsants, anticonvulsives, sodium, channels, voltage-gated, Na+, voltage-dependent, inhibitors, inhibits, NaV, GP47779, GP, 47779, GP, 47779, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience

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