Chemical Name: 10,11-Dihydro-10-oxo-5H-dibenzo(Z)[b,f]azepine-5-carboxamide
Purity: ≥98% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Anticonvulsant; protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Thought to act via inhibition of sodium channel activity.
Technical Data
M. Wt
252.27
Formula
C15H12N2O2
Storage
Store at RT
Purity
≥98% (HPLC)
CAS Number
28721-07-5
PubChem ID
34312
InChI Key
CTRLABGOLIVAIY-UHFFFAOYSA-N
Smiles
NC(N(C(C=CC=C3)=C3C2)C1=CC=CC=C1C2=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
12.61
50
Preparing Stock Solutions
The following data is based on the product molecular weight 252.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.96 mL
19.82 mL
39.64 mL
5 mM
0.79 mL
3.96 mL
7.93 mL
10 mM
0.4 mL
1.98 mL
3.96 mL
50 mM
0.08 mL
0.4 mL
0.79 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
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References
References are publications that support the products' biological activity.
Schmutzet al (1994) Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action. Epilepsia 35 S47 PMID: 8039471
Ambrosioet al (2002) Mechanism of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem.Res. 27 121 PMID: 11926264
Zhenget al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83 PMID: 18717705