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Tocris/Sinomenine hydrochloride/3848/50/50 mg

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货号: 3848/50

品牌: Tocris

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Description: Anti-inflammatory; causes mast cell degranulation and histamine release

Chemical Name: 9α,13α,14α -7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Natural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro.

Technical Data

M. Wt	365.85
Formula	C₁₉H₂₃NO₄.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	6080-33-7
PubChem ID	90488887
InChI Key	YMEVIMJAUHZFMW-QKCNXVMZSA-N
Smiles	CN4C2[C@]3([H])[C@@](CC(C(OC)=C3)=O)(CC4)C1=C(O)C(OC)=CC=C1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	36.59	100

Preparing Stock Solutions

The following data is based on the product molecular weight 365.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.67 mL	27.33 mL
5 mM	0.55 mL	2.73 mL	5.47 mL
10 mM	0.27 mL	1.37 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Yamasaki (1976) Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med.Okayama 30 1 PMID: 61710

Desbordes et al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602 PMID: 18522853

Wang et al (2008) Activation of opioid μ-receptor by sinomenine in cell and mice. Neurosci.Lett. 443 209 PMID: 18692550

Qian et al (2007) Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J.Neuroinflamm. 4 23 PMID:

Keywords: Sinomenine hydrochloride, supplier, morphinan, analogs, anti-inflammatory, antinociceptive, histamine, mu-opioid, m-opioid, μ-opioid, opioids, agonists, stem, cells, Histaminergic-Related, Compounds, Mu, Opioid, Receptors, Stem, Cell, Proliferation, Histaminergic-Related, Compounds, Tocris Bioscience

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