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Tocris/SBHA/3810/50/50 mg

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货号: 3810/50

品牌: Tocris

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Description: Histone deacetylase inhibitor

Chemical Name: N,N'-Dihydroxyoctanediamide

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Histone deacetylase (HDAC) inhibitor (ID₅₀ values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (Cat. No. 3257) in colorectal cancer cells.

Compound Libraries

SBHA is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	204.22
Formula	C₈H₁₆N₂O₄
Storage	Store at +4°C
CAS Number	38937-66-5
PubChem ID	5173
InChI Key	IDQPVOFTURLJPT-UHFFFAOYSA-N
Smiles	O=C(CCCCCCC(NO)=O)NO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.42	100
	water	20.42	100

Preparing Stock Solutions

The following data is based on the product molecular weight 204.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.9 mL	24.48 mL	48.97 mL
5 mM	0.98 mL	4.9 mL	9.79 mL
10 mM	0.49 mL	2.45 mL	4.9 mL
50 mM	0.1 mL	0.49 mL	0.98 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (2004) The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. Mol.Cancer.Ther. 3 425 PMID: 15078986

Brinkmann et al (2001) Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. J.Biol.Chem. 276 22491 PMID: 11304533

Richon et al (1998) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc.Natl.Acad.Sci.U.S.A 95 3003 PMID: 9501205

Keywords: SBHA, supplier, HDAC, inhibits, inhibitors, histone, deacetylases, induces, inducers, of, apoptosis, epigenetics, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience

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