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Tocris/Sildenafil citrate/3784/10/10 mg

价格: ¥1908.00 市场价: 3180.00

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货号: 3784/10

品牌: Tocris

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Description: Orally active, potent PDE5 inhibitor

Chemical Name: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC₅₀ = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Sildenafil citrate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	666.7
Formula	C₂₂H₃₀N₆O₄S.C₆H₈O₇
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	171599-83-0
PubChem ID	62853
InChI Key	DEIYFTQMQPDXOT-UHFFFAOYSA-N
Smiles	O=C(O)C(O)(CC(O)=O)CC(O)=O.CN1CCN(S(C2=CC=C(OCC)C(C(NC4=C3N(C)N=C4CCC)=NC3=O)=C2)(=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	66.67	100

Preparing Stock Solutions

The following data is based on the product molecular weight 666.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.5 mL	7.5 mL	15 mL
5 mM	0.3 mL	1.5 mL	3 mL
10 mM	0.15 mL	0.75 mL	1.5 mL
50 mM	0.03 mL	0.15 mL	0.3 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Ballard et al (1998) Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J.Urol. 159 2164 PMID: 9598563

Turko et al (1999) Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds. Mol.Pharmacol. 56 124 PMID: 10385692

Ghofrani et al (2006) Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat.Rev.Drug Discov. 5 689 PMID: 16883306

Keywords: Sildenafil citrate, supplier, phosphodiesterases, 5, PDE5, inhibitors, inhibits, orally, active, potent, Pfizer, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

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