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Tocris/CP 471474/3780/50/50 mg

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货号: 3780/50

品牌: Tocris

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Description: Broad spectrum MMP inhibitor

Chemical Name: 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide

Purity: ≥97% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Broad spectrum MMP inhibitor (IC₅₀ values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

CP 471474 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	368.38
Formula	C₁₆H₁₇FN₂O₅S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	210755-45-6
PubChem ID	9907286
InChI Key	QCOQJYRPDUMCNP-UHFFFAOYSA-N
Smiles	FC1=CC=C(OC2=CC=C(S(NC(C)(C)C(NO)=O)(=O)=O)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.84	100

Preparing Stock Solutions

The following data is based on the product molecular weight 368.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.57 mL	27.15 mL
5 mM	0.54 mL	2.71 mL	5.43 mL
10 mM	0.27 mL	1.36 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Rohde et al (1999) Matrix metalloproteinease inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation 99 3063 PMID: 10368126

Lindsey et al (2002) Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation 105 753 PMID: 11839633

Fang et al (2007) Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J.Mol.Cell.Cardiol. 43 535 PMID: 17689559

Keywords: CP 471474, supplier, CP471474, MMP, matrix, metalloproteinase, metalloprotease, inhibitors, inhibits, broad, spectrum, proteinases, proteases, Pfizer, Matrix, Metalloprotease, Matrix, Metalloprotease, Tocris Bioscience

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