Description: Anticonvulsant; selectively binds the α2δ subunit of voltage-sensitive calcium channels
Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
M. Wt
159.23
Formula
C8H17NO2
Storage
Store at RT
CAS Number
148553-50-8
PubChem ID
5486971
InChI Key
AYXYPKUFHZROOJ-ZETCQYMHSA-N
Smiles
CC(C)C[C@H](CN)CC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
water
15.92
100
Preparing Stock Solutions
The following data is based on the product molecular weight 159.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
6.28 mL
31.4 mL
62.8 mL
5 mM
1.26 mL
6.28 mL
12.56 mL
10 mM
0.63 mL
3.14 mL
6.28 mL
50 mM
0.13 mL
0.63 mL
1.26 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Fieldet al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1 PMID: 11156553
Kumaret al (2010) Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552 PMID: 20132471
Arain
(2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407 PMID:
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