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Tocris/MCOPPB trihydrochloride/3763/10/10 mg

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货号: 3763/10

品牌: Tocris

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Description: Potent NOP receptor agonist

Chemical Name: 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole trihydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

High affinity NOP receptor agonist (pK_i = 10.07 for the human NOP receptor). Exhibits anxiolytic effects with no effect on memory or locomotion. Regarded as one of the most potent, non-peptide NOP full agonists in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

MCOPPB trihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	534.05
Formula	C₂₆H₄₀N₄.3HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1108147-88-1
PubChem ID	25208093
InChI Key	DTIPEVOPCGEULQ-RFCADEKQSA-N
Smiles	CC5(CCCCCCC5)N(CC4)CCC4N2C1=CC=CC=C1N=[C@@]2[C@H]3CNCCC3.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.04	60
	water	16.02	30

Preparing Stock Solutions

The following data is based on the product molecular weight 534.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.36 mL	18.72 mL
5 mM	0.37 mL	1.87 mL	3.74 mL
10 mM	0.19 mL	0.94 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Hirao et al (2008) Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent. J.Pharmacol.Sci. 106 361 PMID: 18319566

Hayashi et al (2009) Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain f J.Med.Chem. 52 610 PMID: 19125610

Keywords: MCOPPB trihydrochloride, supplier, MCOPPB, trihydrochloride, antianxiety, anxiolytic, NOP, receptor, full, agonist, NOP, Receptors, NOP, Receptors, Tocris Bioscience

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