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Tocris/Dofetilide/3757/10/10 mg

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货号: 3757/10

品牌: Tocris

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Description: K_V11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K⁺ current (I_Kr)

Alternative Names: Tikosyn, UK 68798

Chemical Name: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective potassium channel blocker. Blocks K_V11.1 (hERG) channels; inhibits the rapid delayed-rectifier K⁺ current (I_Kr). Displays class III antiarrhythmic properties.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Dofetilide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	441.56
Formula	C₁₉H₂₇N₃O₅S₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	115256-11-6
PubChem ID	71329
InChI Key	IXTMWRCNAAVVAI-UHFFFAOYSA-N
Smiles	CN(CCC2=CC=C(NS(=O)(C)=O)C=C2)CCOC1=CC=C(NS(=O)(C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.16	100

Preparing Stock Solutions

The following data is based on the product molecular weight 441.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.32 mL	22.65 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Gwilt et al (1991) UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J.Pharmacol.Exp.Ther. 256 318 PMID: 1988662

Carmeliet (1992) Voltage- and time-dependent block of delayed K⁺ current in cardiac myocytes by dofetilide. J.Pharmacol.Exp.Ther. 262 809 PMID: 1501123

Finlayson et al (2001) [³H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K⁺ channel. Eur.J.Pharmacol. 412 203 PMID: 11166283

Keywords: Dofetilide, supplier, UK68798, hERG, K+, potassium, channels, blockers, inhibits, IKR, delayed, rectifier, currents, Kv, voltage-gated, voltage-dependent, Human, Ether-A-Go-Go, Gene, Pfizer, KV11.1, Tikosyn, UK, 68798, Voltage-Gated, Potassium, Channels, Voltage-Gated, Potassium, Channels, Tocris Bioscience

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