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Tocris/VU 0361737/3707/50/50 mg

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货号: 3707/50

品牌: Tocris

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Description: Selective positive allosteric modulator at mGlu₄

Chemical Name: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective positive allosteric modulator at mGlu₄ receptors (EC₅₀ values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu₁, mGlu₂, mGlu₃, mGlu₆ and mGlu₇ receptors and displays weak activity at mGlu₅ and mGlu₈ receptors. Brain penetrant.

Compound Libraries

VU 0361737 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	262.69
Formula	C₁₃H₁₁ClN₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1161205-04-4
PubChem ID	44191096
InChI Key	ARYUXFNGXHNNDM-UHFFFAOYSA-N
Smiles	ClC1=C(OC)C=C(NC(C2=NC=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.27	100

Preparing Stock Solutions

The following data is based on the product molecular weight 262.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.81 mL	19.03 mL	38.07 mL
5 mM	0.76 mL	3.81 mL	7.61 mL
10 mM	0.38 mL	1.9 mL	3.81 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Engers et al (2009) Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J.Med.Chem. 52 4115 PMID: 19469556

Engers et al (2011) Discovery, synthesis, and structure-activity relationship development of a series of N-(4-Acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats. J.Med.Chem. 54 1106 PMID: 21247167

Keywords: VU 0361737, supplier, Selective, positive, allosteric, modulators, mGlu4, mGluR4, group, III, metabotropic, glutamate, receptors, VU0361737, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

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