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Potentp38αinhibitor(IC50=9nM).Alsoinhibitsp38βandJNK-2(IC50valuesare90nMand100nMrespectively).Displaysnosignificantactivityatp38γ,p38δ,ERK-2andJNK-1.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight483.96.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
LeeandDominguez(2005)MAPkinasep38inhibitors:clinicalresultsandanintimatelookattheirinteractionswithp38αprotein.Curr.Med.Chem.122979PMID:16378500
Keywords:SX011,supplier,SX011,p38,inhibitors,inhibits,MAPK,p38alpha,p38beta,p38a,p38b,signaling,signalling,Mitogen-Activated,Protein,Kinases,p38,p38,TocrisBioscience
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