Description:Potentcalcineurininhibitor;immunosuppressant
AlternativeNames:Tacrolimus,Fujimycin
ChemicalName:(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potentcalcineurin(proteinphosphatase2B)inhibitorthatrequiresFK506-bindingprotein12(FKBP12)foractivity(IC50=3nM).InhibitssecretionofIL-1,IL-2(IC50=1nM),IL-3,IL-4,IL-6(IC50=35nM),GM-CSF,TNFα(IC50=10nM),IFNγandMycfromactivatedTcellsinvitro.Exhibitspotentimmunosuppressive,neuroprotectiveandanticonvulsantactivityinvivo.Analog(ascomycin,Cat.No.4210)alsoavailable.
TechnicalData
| M.Wt | 804.02 |
| Formula | C44H69NO12 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 104987-11-3 |
| PubChemID | 445643 |
| InChIKey | QJJXYPPXXYFBGM-LFZNUXCKSA-N |
| Smiles | O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 80.4 | 100 |
| ethanol | 80.4 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight804.02.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.24mL | 6.22mL | 12.44mL |
| 5mM | 0.25mL | 1.24mL | 2.49mL |
| 10mM | 0.12mL | 0.62mL | 1.24mL |
| 50mM | 0.02mL | 0.12mL | 0.25mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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