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Tocris/Topiramate/3620/10/10 mg

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货号: 3620/10

品牌: Tocris

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Description: GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV

Alternative Names: Topamax

Chemical Name: 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Anticonvulsant. Antagonizes GluR5 kainate receptors (IC₅₀ = 0.46 μM), acts as a positive allosteric modulator of GABA_A receptor-mediated currents, inhibits Na_v channels (IC₅₀ = 48.9 μM) and inhibits L-type Ca²⁺ channels. Also inhibits carbonic anhydrase (CA) (K_i values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.

Compound Libraries

Topiramate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	339.36
Formula	C₁₂H₂₁NO₈S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	97240-79-4
PubChem ID	5284627
InChI Key	KJADKKWYZYXHBB-XBWDGYHZSA-N
Smiles	CC(O2)(C)O[C@H]1[C@@H]2[C@H](OC(C)(C)O3)[C@@]3(COS(N)(=O)=O)OC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.94	100
	ethanol	33.94	100

Preparing Stock Solutions

The following data is based on the product molecular weight 339.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.73 mL	29.47 mL
5 mM	0.59 mL	2.95 mL	5.89 mL
10 mM	0.29 mL	1.47 mL	2.95 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Zona et al (1997) Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells. Neurosci.Lett. 231 123 PMID: 9300637

Dodgson et al (2000) Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia 41 S35 PMID: 10768298

Gryder and Rogawski (2003) Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons. J.Neurosci. 23 7069 PMID: 12904467

Kaminiski et al (2004) Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology 46 1097 PMID: 15111016

Keywords: Topiramate, supplier, GluR5, antagonists, anticonvulsant, GABAA, receptor, positive, allosteric, modulators, Glutamate, Kainate, Receptors, iGluR, Ionotropic, Topamax, Kainate, Receptors, GABAA, Receptors, Carbonic, anhydrases, Kainate, Receptors, Tocris Bioscience

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