Overview | Theracemicmixtureofacell-permeableoxADIazolo-benzofuranylphenylsulfoxidethatinhibitsGSK-3β(IC50=35,34,and140nMusingtheracemate,the(S),andthe(R)enantiomer,respectively)inahighlyselectivemanner.TheeutomerisshowntobeorallyactiveinratsandmiceandsignificantlyreduceCWS-inducedbraintauThr205phosphorylationinmiceinvivo. |