Overview | Acell-permeablemaleimidecompoundthatactsasapotent,reversIBLe,andATP-competitiveinhibitoragainstGSK-3β(Cat.No.361524)activity(IC50=34,67and304nMinthepresenceof10,30and100µMATP,respectively),whileexhibitingmuchreducedactivityagainstCdk2/A,KDR(71%and53%inhibition,respectively,at5µMinhibitorconcentration),andapanelof19otherkinases(IC50>5µM).ShowntopotentlyactivatecellularWntpathwayandincreaseβ-catenin-dependentreportertranscription(by15-foldat4µM)in293Tculturesinvitroand,whenappliedatorpriortotheshieldstageofembryo,interferewithzebrafishforebraindevelopmentinvivo. |