Overview | AnacetoximeanalogofBIO,GSK-3InhibitorIX(Cat.No.361550)thatexhibitsgreaterselectivityforGSK-3α/β(IC50=10nM)overCdk5/p25,Cdk2/AandCdk1/B(IC50=2.4µM,4.3µMand63µM,respectively).WeaklyaffectstheactivitiesofCdk4/D1andmanyotherkinases(IC50≥10µM).AlsoactsasanarylhydrocarbonreceptoragoNISTinbothyeast(EC50≥0.1µM)andmammalian(EC50=0.16µM)reportersystems. |