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Tocris/Voglibose/3596/10/10 mg

价格: ¥2028.00 市场价: 3380.00

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货号: 3596/10

品牌: Tocris

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Description: Orally active α-glucosidase inhibitor

Chemical Name: 3,4-Dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epi-inositol

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Orally active α-glucosidase inhibitor (IC₅₀ values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.

Compound Libraries

Voglibose is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	267.28
Formula	C₁₀H₂₁NO₇
Storage	Store at -20°C
CAS Number	83480-29-9
PubChem ID	444020
InChI Key	FZNCGRZWXLXZSZ-CIQUZCHMSA-N
Smiles	O[C@@H]1[C@](CO)(O)C[C@H](NC(CO)CO)[C@H](O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.05	75
	water	26.73	100

Preparing Stock Solutions

The following data is based on the product molecular weight 267.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.74 mL	18.71 mL	37.41 mL
5 mM	0.75 mL	3.74 mL	7.48 mL
10 mM	0.37 mL	1.87 mL	3.74 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Matsuo et al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S PMID: 1728846

Matsui et al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559 PMID: 19359799

Moritoh et al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669 PMID: 19208898

Keywords: Voglibose, supplier, Orally, active, α-glucosidase, alpha-glucosidase, inhibitors, inhibits, Glycosylases, Glycosylases, Glycosylases, Tocris Bioscience

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