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Tocris/Goserelin acetate/3592/10/10 mg

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货号: 3592/10

品牌: Tocris

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Description: GnRH receptor agonist

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.

Technical Data

M. Wt	1269.42
Formula	C₅₉H₈₄N₁₈O₁₄
Sequence	XHWSYSLRP (Modifications: X = Pyr, Ser-4 = t-Bu-Ser, Pro-9 = terminal NH-NH-CO-NH2)
Storage	Desiccate at -20°C
CAS Number	145781-92-6
PubChem ID	90488862
InChI Key	BLCLNMBMMGCOAS-JFBCNRKLSA-N
Smiles	[H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O)C(=O)C1CCC(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble in water

Solubility

Soluble in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1269.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.79 mL	3.94 mL	7.88 mL
5 mM	0.16 mL	0.79 mL	1.58 mL
10 mM	0.08 mL	0.39 mL	0.79 mL
50 mM	0.02 mL	0.08 mL	0.16 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Dondi et al (1994) Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54 4091 PMID: 8033142

Chatzaki et al (1996) The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 56 2059 PMID: 8616851

Chrisp and Goa (1991) Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs 2 254 PMID:

Keywords: Goserelin acetate, supplier, GnRH, receptor, antagonists, Receptors, gonadotropin, Gonadotrophin-Releasing, Hormone, ICI118630, chemotherapeutics, Gonadotrophin-Releasing, Hormone, Receptors, Gonadotrophin-Releasing, Hormone, Receptors, Tocris Bioscience

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