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Tocris/Xanomeline oxalate/3569/10/10 mg

价格: ¥2028.00 市场价: 3380.00

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货号: 3569/10

品牌: Tocris

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Description: Functionally selective M₁ agonist

Chemical Name: 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Functionally selective muscarinic M₁ receptor agonist (EC₅₀ values are 0.3, 5, 42, 52 and 92.5 nM at M₁, M₃, M₅, M₄ and M₂ receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M₁; delayed wash-resistant partial agonist activity at M₂; and delayed wash-resistant full agonist activity at M₄. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.

Compound Libraries

Xanomeline oxalate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	371.46
Formula	C₁₄H₂₃N₃OS.C₂H₂O₄
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	141064-23-5
PubChem ID	18920248
InChI Key	ZJOUESNWCLASJP-UHFFFAOYSA-N
Smiles	CCCCCCOC1=NSN=C1C2=CCCN(C)C2.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.15	100
	ethanol	9.29	25
	water	3.71	10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 371.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Jakubik et al (2008) Importance and prospects for design of selective muscarinic agonists. Physiol.Res. 57 S39 PMID: 18481916

Heinrich et al (2009) Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M₁-preferring receptor agonists. Eur.J.Pharmacol. 605 53 PMID: 19168056

Stanhope et al (2001) The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat. J.Pharmacol.Exp.Ther. 299 782 PMID:

Keywords: Xanomeline oxalate, supplier, Functionally, selective, M1, agonists, Muscarinic, Receptors, Acetylcholine, ACh, M1, Receptors, M1, Receptors, Tocris Bioscience

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