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Tocris/CRSP-1/3555/100U/100 ug

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货号: 3555/100U

品牌: Tocris

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Description: Endogenous central calcitonin receptor agonist

Alternative Names: Calcitonin receptor-stimulating peptide-1

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED₅₀ values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin receptors. Inhibits formation of multinuclear osteoclasts with similar efficacy to CT in vitro. Suppresses food intake and increases body temperature in free-feeding rats, and significantly decreases plasma calcium levels in vivo.

Technical Data

M. Wt	4098.88
Formula	C₁₇₅H₂₉₄N₅₄O₄₉S₅
Sequence	SCNTATCMTHRLVGLLSRSGSMVRSNLLPTKMGFKVFG (Modifications: Disulfide bridge between 2 - 7, Gly-38 = C-terminal amide)
Storage	Store at -20°C
CAS Number	697327-12-1
PubChem ID	90488857
InChI Key	GZXYZTLKVIEHJD-BDNMSBJBSA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 0.50 mg/ml in 10% acetonitrile / water

Solubility

Soluble to 0.50 mg/ml in 10% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 4098.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.24 mL	1.22 mL	2.44 mL
5 mM	0.05 mL	0.24 mL	0.49 mL
10 mM	0.02 mL	0.12 mL	0.24 mL
50 mM	0 mL	0.02 mL	0.05 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Katafuchi et al (2003) Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity. J.Biol.Chem. 278 12046 PMID: 12556539

Sawada et al (2006) Central effects of calcitonin receptor-stimulating peptide-1 on energy homeostasis in rats. Endocrinology 147 2043 PMID: 16410305

Notoya et al (2007) A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts. Eur.J.Pharmacol. 560 234 PMID: 17328890

Keywords: CRSP-1, supplier, Endogenous, central, CT, receptors, calcitonin, agonists, Calcitonin, receptor, stimulating, peptide1, Calcitonin, receptor-stimulating, peptide-1, Calcitonin, and, Related, Receptors, Calcitonin, and, Related, Receptors, Tocris Bioscience

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