当前位置： Tocris >>> Tocris/Sirtinol/3521/10/10 mg

Tocris/Sirtinol/3521/10/10 mg

价格: ¥2028.00 市场价: 3380.00

打印产品信息

货号: 3521/10

品牌: Tocris

规格

默认

数量

库存(0)

特别提示

代购产品：无质量问题不接受退换货，下单前请仔细核对信息。
下单后请及时联系客服核对商品价格，订单生效后再付款。

立即购买加入购物车

收藏商品

资深产品顾问

咨询顾问

全国免费服务热线

4000-520-616

自营商城一站式服务
厂家直采剔除溢价
品质甄选正品保证
严控流程只做188精品
极速物流如约送货

详情
使用说明
常见问题

Description: Selective sirtuin family deacetylase inhibitor

Chemical Name: 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cell-permeable, selective sirtuin deacetylase inhibitor (IC₅₀ values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

Compound Libraries

Sirtinol is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	394.47
Formula	C₂₆H₂₂N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	410536-97-9
PubChem ID	5717148
InChI Key	YUGODMKHHCZZOI-QJOMJCCJSA-N
Smiles	O=C(NC(C)C3=CC=CC=C3)C1=CC=CC=C1/N=C/C2=C(C=CC=C4)C4=CC=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.45	100

Preparing Stock Solutions

The following data is based on the product molecular weight 394.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.68 mL	25.35 mL
5 mM	0.51 mL	2.54 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Grozinger et al (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J.Biol.Chem. 276 38837 PMID: 11483616

Mai et al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789 PMID: 16302818

Kahyo et al (2008) A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J.Pharmacol.Sci. 108 364 PMID: 19008647

Jung-Hynes et al (2009) Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J.Biol.Chem. 284 3823 PMID: 19075016

Keywords: Sirtinol, supplier, Selective, sirtuin, family, deacetylases, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Sir2-like, Family, Deacetylases, Sir2-like, Family, Deacetylases, Tocris Bioscience

售后保障

蚂蚁淘生物188，秉承蚂蚁淘一贯的严谨态度，由蚂蚁淘公司专业人员负责品控、采购、物流、销售、售后，保障正品优质。以“快速好省，为科研提供好产品、好价格”为理念，直接链接原厂家，从全国各地原制造商严格挑选188款科研精品，剔除品牌溢价，188生物新电商，把好的产品带给科研！力求给你最优质的商品。

Q：生物188产品正品保障吗？
A：生物188质量把控人员具有十年的从业经验，在业界享有良好的口碑；自营商城，直接从厂家采购，自己的团队负责国际物流和清关，中间没有第三方，所有流程严格把控，100%保证正品，假一罚十。

Q：下单后可以修改订单吗？
A：下单后的商品付款之前可以修改；订单付款成功，需要联系我们客服进行修改；客服电话：4000-520-616

Q：可以开发票吗？
A：本网站所售商品都是正规清关，均开具16%正规发票，发票金额含配送费金额，另有说明的除外。

Q：商品几天可以发货？
A：生物188商品，全部现货销售，付款后即可发货,一般一周内送达！

Q：如何联系商家？
A：有任何问题够可以电话咨询我们，全国24小时免费服务热线：4000-520-616 或联系我们的在线客服QQ：1570468124

Q：收到的商品少了/发错了怎么办？
A：同个订单购买多个商品可能会分为一个以上包裹发出，可能不会同时送达，建议查看订单详情是否是部分发货状态；如未收到，可联系在线客服或者致电4000-520-616。

Q：退换货/维修需要多长时间？
A：一般情况下，退货处理周期为客户收到产品一个月内（以快递公司显示签收时间为准），包装规格、数量、品种不符，外观毁损、短缺或缺陷，请在收到货24小时内申请退换货；特殊商品以合同条款为准。