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PurineanalogthatinhibitsDNAsynthesis.Exhibitsantiproliferativeactivity(IC50=1.54μMinRPMIcells)andtriggersapoptosisthroughincreasingBaxanddecreasingBid,XIAPandsurvivinexpression.Inhibitscytokine-inducedactivationofSTAT1andSTAT1-dependentgenetranscriptioninlymphocytes.Alsodisplaysanticanceractivityagainsthematologicalmalignanciesinvivo.
FludarabineisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 285.23 |
| Formula | C10H12FN5O4 |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 21679-14-1 |
| PubChemID | 657237 |
| InChIKey | HBUBKKRHXORPQB-FJFJXFQQSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(F)=NC(N)=C2N=C3)[C@H]1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.52 | 100 |
Thefollowingdataisbasedontheproductmolecularweight285.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.51mL | 17.53mL | 35.06mL |
| 5mM | 0.7mL | 3.51mL | 7.01mL |
| 10mM | 0.35mL | 1.75mL | 3.51mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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