Overview | Acell-permeableoxobutananilidecompoundthatispredictedtointeractwithGlut(GlucoseTransporter)atanintracellularsitebasedonavirtualdockingstudyandshowntoinhibitGlut-mediatedcellularglucoseuptake(50%and80%inhibitionof2-deoxy-D-glucoseuptakeinGlut1-andGlut4-overexpressingL6myoblasts,respectively,at300µM).Fas-resistantcelllinesthataremadeFas-responsiveuponmediumglucosedeprivationarealsoshowntobesensitizedbyFasentintoFas-mediatedcelldeath(ED50=35µMinPPC-1cultures),whilecellsthatremainFas-resistantuponglucosedeprivation,e.g.DU145,areshownnottobesensitizedbyFasentintoFas-mediateddeath. |