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Tocris/Tubacin/3402/1/1 mg

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货号: 3402/1

品牌: Tocris

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Description: HDAC6 inhibitor; inhibits α-tubulin deacetylation

Chemical Name: N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective inhibitor of HDAC6; inhibits the second deacetylase domain (DD2). Does not inhibit HDAC6 histone deacetylase activity; reversibly inhibits α-tubulin deacetylation. Increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Tubacin is reviewed on the Chemical Probes website.

Technical Data

M. Wt	721.86
Formula	C₄₁H₄₃N₃O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1350555-93-9
PubChem ID	6675804
InChI Key	BHUZLJOUHMBZQY-YXQOSMAKSA-N
Smiles	OCC(C=C4)=CC=[C@@]4[C@@H]1C[C@H](CSC2=NC(C6=CC=CC=C6)=C(C5=CC=CC=C5)O2)O[C@H]([C@]3=CC=C(NC(CCCCCCC(NO)=O)=O)C=C3)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.22	10

Preparing Stock Solutions

The following data is based on the product molecular weight 721.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.39 mL	6.93 mL	13.85 mL
5 mM	0.28 mL	1.39 mL	2.77 mL
10 mM	0.14 mL	0.69 mL	1.39 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Haggarty et al (2003) Multidimensional chemical genetic analysis of diversity-orientated synthesis-derived deacetylase inhibitors using cell-based assays. Chem.Biol. 10 383 PMID: 12770821

Haggarty et al (2003) Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc.Natl.Acad.Sci.USA 100 4389 PMID: 12677000

Jiang et al (2008) Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. J.Neurosci. 28 12993 PMID: 19036992

Keywords: Tubacin, supplier, Tubacin, HDAC, inhibitors, class, II, histone, deacetylase, inhibits, deacetylases, alpha-tubulin, α-tubulin, a-tubulin, acetylation, HDAC6, epigenetics, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience

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