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Tocris/CGP 52411/3360/50/50 mg

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货号: 3360/50

品牌: Tocris

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Description: EGFR inhibitor. Also inhibits Aβ42 fibril formation

Alternative Names: DAPH

Chemical Name: 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective inhibitor of the epidermal growth factor receptor (EGFR) (IC₅₀ = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca²⁺ influx into neuronal cells.

Compound Libraries

CGP 52411 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	329.35
Formula	C₂₀H₁₅N₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	145915-58-8
PubChem ID	1697
InChI Key	AAALVYBICLMAMA-UHFFFAOYSA-N
Smiles	O=C2NC(C1=CC(NC4=CC=CC=C4)=C(NC3=CC=CC=C3)C=C12)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.94	100
	ethanol	8.23	25

Preparing Stock Solutions

The following data is based on the product molecular weight 329.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.18 mL	30.36 mL
5 mM	0.61 mL	3.04 mL	6.07 mL
10 mM	0.3 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.3 mL	0.61 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Buchdunger et al (1994) 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 91 2334 PMID: 8134396

Blanchard et al (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 101 14326 PMID: 15388848

Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 105 7159 PMID: 18480256

Keywords: CGP 52411, supplier, abeta42, ab42, aβ42, fibers, fibres, fibrils, epidermal, growth, factors, receptors, EGFR, Alzheimers, disease, CGP52411, amyloidbeta, amyloidb, amyloidβ, DAPH, EGFR, Amyloid, Beta, Peptides, EGFR, Tocris Bioscience

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